Female-specific reference values for blood pressure and its relationship with subclinical echocardiographic findings in women with a history of preeclampsia: the Queen of Hearts study

Abstract Introduction Hypertension is the most crucial modifiable risk factor for cardiovascular disease (CVD). Sex differences in what considered optimal blood pressure (BP) might deviate from current sex-blinded guidelines hypertension. In women, an obstetric history of preeclampsia relates to postpartum hypertension and substantially increases premature CVD. Purpose To establish female-specific reference values BP relatively young women assess its association with subclinical aberrant echocardiographic findings a high-risk female population. Methods Data was used Queen Hearts study; cross-sectional cohort study on early detection heart failure among control group low-risk healthy uncomplicated pregnancy. The non-parametrically (95th percentile). between derived evaluated former preeclamptic using logistic regression. All were admitted standardized assessment including transthoracic echocardiography 30-minutes measurement. Subclinical included left ventricular (LV) hypertrophy (LVH), LV concentric remodelling (LCVR), diastolic dysfunction (DD) impaired ejection fraction (LVEF, <55%). Results A total 429 856 (44±8 38±8 years, respectively). group, 97.7% 99.8% had systolic (SBP) (DBP) value below European Society Cardiology (ESC) Overall, SBP DBP our 133 82 mmHg, respectively. Age-specific curves are presented Figure 1 2. subgroup 10.4% 14.6% levels above mmHg 82mmHg, this Odds Ratio (OR) when having ≥133mmHg 5.3 (95% CI 2.3–12.3) LVH, 1.4 0.6–3.2) LVCR, 5.9 3.3–10.7) DD 1.3 0.3–6.0) LVEF. For ≥82mmHg, OR LVH 3.5 1.5–8.0), LVCR 0.6–2.7), 3.4 1.9–6.0) LVEF 1.5 0.4–5.3). Conclusions Upper limits correspond less than 2% (no pre-eclampsia) We new upper limit corresponding 5th centile. Values level, even decision hypertension, associated abnormal cardiac function geometry Funding Acknowledgement Type funding sources: Public grant(s) – National budget only. Main source(s): Dutch Heart Foundation